Enzyme associated with stomach cancer and osteoporosis seen in detail for the first time with neutron crystallography
• The enzyme PKG II is associated with stomach cancer causing 754,000 deaths worldwide
• The activation process for the enzyme has been looked at in exceptional detail with neutron crystallography
• Understanding such mechanisms will enable future drug development for stomach cancer and osteoporosis
The enzyme PKG II (protein kinase G II – a cyclic guanosine monophosphate dependent kinase) plays an important role in human health, but can increase the risk of diseases like stomach cancer and osteoporosis if not activated. Stomach cancer kills 754,000 people globally each year and osteoporosis, which causes weakened bones, affects over 200 million people worldwide , so researchers are keen to understand how this enzyme...