Jia-Fei Poon
-
Mailjia-fei.poon [at] ess.eu
-
Mobile
-
ORCID
Research Activities
Chemical and biochemical deuteration of small organic molecules.
Selected Publications
1. Hjalte, J.; Diehl, C.; Leung, A. E.; Poon, J.-F.; Porcar, L.; Dalgliesh, R.; Sjögren, H.; Wahlgren, M.; Sanchez-Fernandez, A. Modulating Protein Unfolding and Refolding via the Synergistic Association of an Anionic and a Nonionic Surfactant. J. Colloid Interface Sci. 2024, 672 (April), 244–255. DOI: 10.1016/j.jcis.2024.05.157.
2. Sanchez-Fernandez, A.; Poon, J.-F.; Leung, A. E.; Prévost, S. F.; Dicko, C. Stabilization of Non-Native Folds and Programmable Protein Gelation in Compositionally Designed Deep Eutectic Solvents. ACS Nano 2024, 18 (28), 18314–18326. DOI: 10.1021/acsnano.4c01950.
3. Farmer, L. A.; Wu, Z.; Poon, J.; Zilka, O.; Lorenz, S. M.; Huehn, S.; Proneth, B.; Conrad, M.; Pratt, D. A. Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death. J. Am. Chem. Soc. 2022, 144 (32), 14706–14721. DOI: 10.1021/jacs.2c05252.
4. Zilka, O.; Poon, J. F.; Pratt, D. A. Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death. J. Am. Chem. Soc. 2021, 143 (45), 19043–19057. DOI: 10.1021/jacs.1c08254.
5. Poon, J.-F.; Zilka, O.; Pratt, D. A. Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals. J. Am. Chem. Soc. 2020, 142 (33), 14331–14342. DOI: 10.1021/jacs.0c06379.
6. Poon, J. F.; Farmer, L. A.; Haidasz, E. A.; Pratt, D. A. Temperature-Dependence of Radical-Trapping Activity of Phenoxazine, Phenothiazine and Their Aza-Analogues Clarifies the Way Forward for New Antioxidant Design. Chem. Sci. 2021, 12 (33), 11065–11079. DOI: 10.1039/d1sc02976b.