Aaron Finke

Aaron Finke

Instrument Data Scientist

Research Activities

  • Data collection strategies for neutron protein crystallography
  • New algorithmic methods for reciprocal space reconstruction
  • Serial crystallography

Selected Publications

  1. Guerrero, L.; Ebrahim, A.; Riley, B. T.; Kim, M.; Huang, Q.; Finke, A. D.; Keedy. D. A. “Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP,” Nat. Commun. Biol. 2023, 7, 59. doi: 10.1038/s42003-023-05609-0
  2. Milano, S. K.; Huang, Q.; Nguyen, T. T.; Ramachandran, S.; Finke, A. D.; Kriksunov, I.; Schuller, D.; Szebenyi, D. M.; Arenholz, E.; McDermott, L. A.; Sukumar, N.; Cerione, R. A.; Katt, W. P. “New Insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography”, J. Biol. Chem. 2022, 298, 101535. doi: 10.1016/j.jbc.2021.101535
  3. Pedrini, B.; Finke, A. D.; Marsh, M.; Luporini, M.; Vallesi, A.; Alimenti, C. “Crystal structure of the pheromone Er-13 from the ciliate Euplotes raikovi, with implications for a protein-protein association model in pheromone/receptor interactions,” J. Struct. Biol. 2022, 214, 107812. doi: 10.1016/j.jsb.2021.107812
  4. Illava, G.; Jayne, R.; Finke, A.D.; Closs, D.; Zeng, W.; Milano, S. K.; Huang, Q.; Kriksunov, I.; Sidorenko, P.; Wise, F. W.; Zipfel, W. R.; Apker, B. A.; Thorne, R. E. “Integrated Sample Handling and Mounting System for Serial Synchrotron Crystallography,” Acta Cryst. 2021, D77, 628-644. doi: 10.1107/S2059798321001868
  5. Wierman, J. L.; Paré-Labrosse, O.; Sarracini, A.; Besaw, J. E.; Cook, M. J.; Oghbaey, S.; Daoud, H.; Mehrabi, P.; Kriksunov, I.; Kuo, A.; Schuller, D. J.; Smith, S.; Ernst, O. P.; Szebenyi, D. M. E.; Gruner, S. M.; Miller, R. J. D.; Finke, A. D. “Fixed-Target Serial Oscillation Crystallography at Room Temperature,” IUCrJ 2019, 6, 305-316. doi: 10.1107/S2052252519001453

Career History

  • 2024 – Present: Instrument Data Scientist at NMX, European Spallation Source
  • 2022 – 2024: Beamline Scientist, MAX IV Laboratory, Sweden
  • 2016 – 2022: Beamline Scientist, Cornell High Energy Synchrotron Source (CHESS), Cornell University, USA
  • 2014 – 2016: Postdoctoral Fellow, Swiss Light Source, Paul Scherrer Institute, Switzerland
  • 2011 – 2014: NSF Postdoctoral Fellow, ETH-Zürich, Switzerland

Education:

  • 2011: PhD in Chemistry, University of Illinois Urbana-Champaign, USA
  • 2006: BS in Chemistry, University of Arizona, USA