presentation at Swedish neutron week

Zoe Fisher

Senior Scientist for Chemistry and Life Science Support
Scientific Activities Division
Science Directorate

Selected Publications

(2024-2019)

  1. Koruza, K., Krupinska, E., Sele, C.P., Vegvari, A., Knecht, W., Fisher, S.Z. (2024) “Botryococcus braunii autolysate for the production of deuterium-labeled recombinant protein.”  Algal Research 79, p.103459, doi:10.1016/j.algal.2024.103459
  2. Sele, C., Krupinska, E., Andersson Rasmussen, A., Ekström, S., Hultgren, L, Lou, J., Kozielski, F., Fisher, S.Z., Knecht, W. (2024) “New insights into complex formation by SARS-CoV-2 nsp10 and nsp14”, Nucleos. Nucleot. Nucl., p.1-15, doi:10.1080/15257770.2024.2321600
  3. Knecht, W., Fisher, Z., Lou, J., Sele, C., Ma, S., Andersson Rasmussen, A., Pinotsis, N., Kozielski, F., (2023) “Oligomeric state of β-coronavirus non-structural protein 10 stimulators studied by Small Angle X-ray Scattering.”, Int. J. Mol. Sci. 24, p.13649. doi:10.3390/ijms241713649.
  4. Raum, H.N., Fisher, S.Z., Weininger, U. (2023) “Energetics and dynamics of the Proton Shuttle of Carbonic Anhydase II”, Cell. Mol. Life Sci. 80, art. 286, doi.org/10.1007/s00018-023-04936-z
  5. Sørensen, H.V.,Montserrat-Canals, M., Loose, J.S.M., Fisher, Z., Moulin, M., Blakeley, M.P., Cordara, G., Bjerregaard-Andersen, K., Krengel, U. (2023) “Perdeuterated GbpA enables neutron scattering experiments of a lytic polysaccharide monooxygenase”, ACS Omega 8, p. 29101-29112. doi: 10.1021/acsomega.3c02168.
  6. Kozielski, F., Sele, C., Talibov, V.O., Lou, J., Dong, D., Wang, Q., Shi, X., Nyblom, M., Rogstam, A., Krojer, T., Fisher, Z., Knecht, W. (2022) “Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16”, RSC Chem. Biol. 3, p.44-55. 
  7. Aggarwal, S., Wachenfeldt, C.V., Fisher, S.Z., Oksanen, E. (2021) “A protocol for production of perdeuterated OmpF porin for neutron crystallography”, Protein Expr Purif. 105954. doi: 10.1016/j.pep.2021.105954. 
  8. Rogstam, A., Nyblom. M., Christensen, S., Sele, C., Talibov, V.O., Lindvall, T., Rasmussen, A.A., André, I., Fisher, S.Z., Knecht, W., Kozielski, F. (2020) “Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2” Int. J. Mol. Sci. 21, p.7375. 
  9. Koruza, K., Murray, A.B., Mahon, B.P., Hopkins, J.B., Knecht, W., McKenna, R., Fisher, S.Z. (2020) “Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX” Int. J. Mol. Sci.  21, p. 5277.
  10. Clabbers, M.T.B., Fisher, S.Z., Coinçon, M., Zou, X., Xu, H. (2020) “Visualizing drug binding interactions using microcrystal electron diffraction” Commun. Biol. 3: 417. 
  11. Budayova-Spano, M., Koruza, K., Fisher, S.Z. (2020) “Large crystal growth for neutron protein crystallography” Methods Enzymol. 634, p.21-46. 
  12. Koruza, K., Lafumat, B., Nyblom, M., Mahon, B.P., McKenna, R., Fisher, S.Z. (2019) “Structural comparison of protiated, H/D exchanged, and deuterated human carbonic anhydrase IX” Acta Cryst D75, p. 895-903.
  13. Koruza, K., Mahon, B.P., Blakeley, M.P., Ostermann, A., Schrader, T., Knecht, W., McKenna, R., Fisher, S.Z. (2019) “Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative” J. Struct. Biol. 205, p. 147-154. 

Career History

Current position(s)

  • Senior Scientist & Team leader for the Deuteration and Macromolecular Crystallization (DEMAX) platform, Scientific Activities Division (SAD), European Spallation Source (ESS), Lund, Sweden (2023 – present)
  • Adjunct Senior Lecturer, Department of Biology & LP3, Lund University, Lund, Sweden (2016 – present)

Previous positions:

  • Group leader (DEMAX), SAD at ESS in Lund, Sweden (2019-2022)
  • Deputy Division Head, for SAD, ESS, Lund, Sweden (2017 – 2023)
  • Research & support scientist, SAD at ESS in Lund, Sweden (2014 – 2018)
  • Research Scientist II, Los Alamos National Laboratory (LANL), Los Alamos NM, USA (2010 – 2014)
  • Postdoctoral Associate (2007-2010) at LANL, Los Alamos NM, USA (2007-2010)

Education

  • Ph.D. in Biochemistry and Molecular Biology (2006). Title: Structural insights into the active site of alpha-carbonic anhydrases.  Advisor: Dr. Robert McKenna, University of Florida (Gainesville FL, USA). 
  • B.Sc. (Hons) in Biochemistry (2000) under the supervision of Dr. Janet Hapgood, University of Stellenbosch (Stellenbosch, South Africa)
  • B.Sc. double majored in Biochemistry and Animal Physiology (1999), University of Stellenbosch (Stellenbosch, South Africa)